TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function

While TGFβ signals are anti-proliferative in benign and well-differentiated pancreatic cells, TGFβ appears to promote the progression of advanced cancers. To better understand dysregulation of the TGFβ pathway, we first generated mouse models of neoplastic disease with TGFβ receptor deficiencies. Th...

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Bibliographische Detailangaben
Veröffentlicht in:Oncogene
Hauptverfasser: Principe, D R, Diaz, A M, Torres, C, Mangan, R J, DeCant, B, McKinney, R, Tsao, M-S, Lowy, A, Munshi, H G, Jung, B, Grippo, P J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537609/
https://ncbi.nlm.nih.gov/pubmed/28368414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.500
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