TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function

While TGFβ signals are anti-proliferative in benign and well-differentiated pancreatic cells, TGFβ appears to promote the progression of advanced cancers. To better understand dysregulation of the TGFβ pathway, we first generated mouse models of neoplastic disease with TGFβ receptor deficiencies. Th...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Principe, D R, Diaz, A M, Torres, C, Mangan, R J, DeCant, B, McKinney, R, Tsao, M-S, Lowy, A, Munshi, H G, Jung, B, Grippo, P J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537609/
https://ncbi.nlm.nih.gov/pubmed/28368414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.500
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