TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function

While TGFβ signals are anti-proliferative in benign and well-differentiated pancreatic cells, TGFβ appears to promote the progression of advanced cancers. To better understand dysregulation of the TGFβ pathway, we first generated mouse models of neoplastic disease with TGFβ receptor deficiencies. Th...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Principe, D R, Diaz, A M, Torres, C, Mangan, R J, DeCant, B, McKinney, R, Tsao, M-S, Lowy, A, Munshi, H G, Jung, B, Grippo, P J
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537609/
https://ncbi.nlm.nih.gov/pubmed/28368414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.500
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