TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell Mediated Regression of Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) remains remarkably lethal with a 5-year survival rate of 8%. This is mainly attributed to the late stage of presentation, as well as widespread resistance to conventional therapy. Additionally, PDAC tumors are largely non-immunogenic, and most patients have di...

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Publicat a:Mol Cancer Ther
Autors principals: Principe, Daniel R., Park, Alex, Dorman, Matthew J., Kumar, Sandeep, Viswakarma, Navin, Rubin, Jonathan, Torres, Carolina, McKinney, Ronald, Munshi, Hidayatullah G., Grippo, Paul J., Rana, Ajay
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397698/
https://ncbi.nlm.nih.gov/pubmed/30587556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0850
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