p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity

Pancreatic ductal adenocarcinoma (PDAC) is notorious for its poor survival and resistance to conventional therapies. PI3K signaling is implicated in both disease initiation and progression, and specific inhibitors of selected PI3K p110 isoforms for managing solid tumors are emerging. We demonstrate...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Torres, Carolina, Mancinelli, Georgina, Cordoba-Chacon, Jose, Viswakarma, Navin, Castellanos, Karla, Grimaldo, Sam, Kumar, Sandeep, Principe, Daniel, Dorman, Matthew J., McKinney, Ronald, Hirsch, Emilio, Dawson, David, Munshi, Hidayatullah G., Rana, Ajay, Grippo, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642408/
https://ncbi.nlm.nih.gov/pubmed/31266893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813012116
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