p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity

Pancreatic ductal adenocarcinoma (PDAC) is notorious for its poor survival and resistance to conventional therapies. PI3K signaling is implicated in both disease initiation and progression, and specific inhibitors of selected PI3K p110 isoforms for managing solid tumors are emerging. We demonstrate...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Torres, Carolina, Mancinelli, Georgina, Cordoba-Chacon, Jose, Viswakarma, Navin, Castellanos, Karla, Grimaldo, Sam, Kumar, Sandeep, Principe, Daniel, Dorman, Matthew J., McKinney, Ronald, Hirsch, Emilio, Dawson, David, Munshi, Hidayatullah G., Rana, Ajay, Grippo, Paul J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642408/
https://ncbi.nlm.nih.gov/pubmed/31266893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813012116
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