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p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its poor survival and resistance to conventional therapies. PI3K signaling is implicated in both disease initiation and progression, and specific inhibitors of selected PI3K p110 isoforms for managing solid tumors are emerging. We demonstrate...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6642408/ https://ncbi.nlm.nih.gov/pubmed/31266893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813012116 |
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