K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling

BRAF plays an indispensable role in activating the MEK/ERK pathway to drive tumorigenesis. Receptor tyrosine kinase and RAS-mediated BRAF activation have been extensively characterized, however, it remains undefined how BRAF function is fine-tuned by stimuli other than growth factors. Here, we repor...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yin, Qing, Han, Tao, Fang, Bin, Zhang, Guolin, Zhang, Chao, Roberts, Evan R., Izumi, Victoria, Zheng, Mengmeng, Jiang, Shulong, Yin, Xiu, Kim, Minjung, Cai, Jianfeng, Haura, Eric B., Koomen, John M., Smalley, Keiran S. M., Wan, Lixin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478693/
https://ncbi.nlm.nih.gov/pubmed/31015455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09844-0
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