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K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
BRAF plays an indispensable role in activating the MEK/ERK pathway to drive tumorigenesis. Receptor tyrosine kinase and RAS-mediated BRAF activation have been extensively characterized, however, it remains undefined how BRAF function is fine-tuned by stimuli other than growth factors. Here, we repor...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478693/ https://ncbi.nlm.nih.gov/pubmed/31015455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09844-0 |
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