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Making Sense of MEK1 Mutations in Intrinsic and Acquired BRAF Inhibitor Resistance
In this issue of Cancer Discovery, Shi and colleagues add further insight into the role of exon 3 MEK1 mutations in BRAF inhibitor resistance by demonstrating the presence of (P124S)MEK1 and (I111S)MEK1 mutations concurrently with (V600E/K)BRAF mutations at baseline in 16% of melanoma specimens. Alt...
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| Publicado no: | Cancer Discov |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5764102/ https://ncbi.nlm.nih.gov/pubmed/22588873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0128 |
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