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Making Sense of MEK1 Mutations in Intrinsic and Acquired BRAF Inhibitor Resistance

In this issue of Cancer Discovery, Shi and colleagues add further insight into the role of exon 3 MEK1 mutations in BRAF inhibitor resistance by demonstrating the presence of (P124S)MEK1 and (I111S)MEK1 mutations concurrently with (V600E/K)BRAF mutations at baseline in 16% of melanoma specimens. Alt...

詳細記述

保存先:
書誌詳細
出版年:Cancer Discov
主要な著者: Paraiso, Kim H. T., Smalley, Keiran S. M.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764102/
https://ncbi.nlm.nih.gov/pubmed/22588873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0128
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