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ITCH as a potential therapeutic target in human cancers
The ITCH/AIP4 ubiquitin E3 ligase was discovered independently by two groups searching for atrophin-1 interacting proteins and studying the genetics of mouse coat color alteration, respectively. ITCH is classified as a NEDD4 family E3 ligase featured with the C-terminal HECT domain for E3 ligase fun...
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| Veröffentlicht in: | Semin Cancer Biol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7724637/ https://ncbi.nlm.nih.gov/pubmed/32165318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2020.03.003 |
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