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Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer
BACKGROUND: Combined MET and BRAF inhibition showed clinical benefit in a patient with rectal cancer carrying BRAF(V600E) and MET amplification. However after 4 months, acquired resistance emerged and the patient deceased shortly after disease progression. The mechanism of resistance to this drug co...
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| Pubblicato in: | Br J Cancer |
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| Autori principali: | , , , , , , , , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5537500/ https://ncbi.nlm.nih.gov/pubmed/28654634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.196 |
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