Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

BACKGROUND: Combined MET and BRAF inhibition showed clinical benefit in a patient with rectal cancer carrying BRAF(V600E) and MET amplification. However after 4 months, acquired resistance emerged and the patient deceased shortly after disease progression. The mechanism of resistance to this drug co...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Br J Cancer
Egile Nagusiak: Oddo, Daniele, Siravegna, Giulia, Gloghini, Annunziata, Vernieri, Claudio, Mussolin, Benedetta, Morano, Federica, Crisafulli, Giovanni, Berenato, Rosa, Corti, Giorgio, Volpi, Chiara Costanza, Buscarino, Michela, Niger, Monica, Dunne, Philip D, Rospo, Giuseppe, Valtorta, Emanuele, Bartolini, Alice, Fucà, Giovanni, Lamba, Simona, Martinetti, Antonia, Di Bartolomeo, Maria, de Braud, Filippo, Bardelli, Alberto, Pietrantonio, Filippo, Di Nicolantonio, Federica
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Translational Therapeutics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537500/
https://ncbi.nlm.nih.gov/pubmed/28654634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.196
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