Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

BACKGROUND: Combined MET and BRAF inhibition showed clinical benefit in a patient with rectal cancer carrying BRAF(V600E) and MET amplification. However after 4 months, acquired resistance emerged and the patient deceased shortly after disease progression. The mechanism of resistance to this drug co...

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Vydáno v:Br J Cancer
Hlavní autoři: Oddo, Daniele, Siravegna, Giulia, Gloghini, Annunziata, Vernieri, Claudio, Mussolin, Benedetta, Morano, Federica, Crisafulli, Giovanni, Berenato, Rosa, Corti, Giorgio, Volpi, Chiara Costanza, Buscarino, Michela, Niger, Monica, Dunne, Philip D, Rospo, Giuseppe, Valtorta, Emanuele, Bartolini, Alice, Fucà, Giovanni, Lamba, Simona, Martinetti, Antonia, Di Bartolomeo, Maria, de Braud, Filippo, Bardelli, Alberto, Pietrantonio, Filippo, Di Nicolantonio, Federica
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537500/
https://ncbi.nlm.nih.gov/pubmed/28654634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.196
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