Prion strains depend on different endocytic routes for productive infection

Prions are unconventional agents composed of misfolded prion protein that cause fatal neurodegenerative diseases in mammals. Prion strains induce specific neuropathological changes in selected brain areas. The mechanism of strain-specific cell tropism is unknown. We hypothesised that prion strains r...

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Udgivet i:Sci Rep
Main Authors: Fehlinger, Andrea, Wolf, Hanna, Hossinger, André, Duernberger, Yvonne, Pleschka, Catharina, Riemschoss, Katrin, Liu, Shu, Bester, Romina, Paulsen, Lydia, Priola, Suzette A., Groschup, Martin H., Schätzl, Hermann M., Vorberg, Ina M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537368/
https://ncbi.nlm.nih.gov/pubmed/28761068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07260-2
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