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Deletion of β-Strand and α-Helix Secondary Structure in Normal Prion Protein Inhibits Formation of Its Protease-Resistant Isoform

A fundamental event in the pathogenesis of transmissible spongiform encephalopathies (TSE) is the conversion of a normal, proteinase K-sensitive, host-encoded protein, PrP-sen, into its protease-resistant isoform, PrP-res. During the formation of PrP-res, PrP-sen undergoes conformational changes tha...

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Detalhes bibliográficos
Main Authors: Vorberg, Ina, Chan, Kaman, Priola, Suzette A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114577/
https://ncbi.nlm.nih.gov/pubmed/11581371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.21.10024-10032.2001
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