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Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates
Aggregation of TDP-43 (transactive response DNA binding protein 43 kDa) is a hallmark of certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Moreover, intracellular TDP-43-positive inclusions are often found in other neurodegenerative diseases. Recently...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5533730/ https://ncbi.nlm.nih.gov/pubmed/28754988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07215-7 |
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