Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates

Aggregation of TDP-43 (transactive response DNA binding protein 43 kDa) is a hallmark of certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Moreover, intracellular TDP-43-positive inclusions are often found in other neurodegenerative diseases. Recently...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Garnier, Cyrille, Devred, François, Byrne, Deborah, Puppo, Rémy, Roman, Andrei Yu., Malesinski, Soazig, Golovin, Andrey V., Lebrun, Régine, Ninkina, Natalia N., Tsvetkov, Philipp O.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533730/
https://ncbi.nlm.nih.gov/pubmed/28754988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07215-7
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