TDP-43 expression influences amyloid β plaque deposition and tau aggregation

Although the main focus in Alzheimer’s disease (AD) has been an investigation of mechanisms causing Aβ plaque deposition and tau tangle formation, recent studies have shown that phosphorylated TDP-43 pathology is present in up to 50% of sporadic cases. Furthermore, elevated phosphorylated TDP-43 has...

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Bibliographic Details
Published in:Neurobiol Dis
Main Authors: Davis, Stephani A., Gan, Kok Ann, Dowell, James A., Cairns, Nigel J., Gitcho, Michael A.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544914/
https://ncbi.nlm.nih.gov/pubmed/28416393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.04.012
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