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Substrate and Lewis Acid Coordination Promote O–O Bond Cleavage of an Unreactive L(2)Cu(II)(2)(O(2)(2−)) Species to Form L(2)Cu(III)(2)(O)(2) Cores with Enhanced Oxidative Reactivity

Copper-dependent metalloenzymes are widespread throughout metabolic pathways, coupling the reduction of O(2) with the oxidation of organic substrates. Small-molecule synthetic analogs are useful platforms to generate L/Cu/O(2) species that reproduce the structural, spectroscopic, and reactive proper...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Garcia-Bosch, Isaac, Cowley, Ryan E., Díaz, Daniel E., Peterson, Ryan L., Solomon, Edward I., Karlin, Kenneth D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532877/
https://ncbi.nlm.nih.gov/pubmed/28195739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b12990
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