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Evaluation of Ligand-Based NMR Screening Methods to Characterize Small Molecule Binding to HIV-1 glycoprotein-41

Small molecule inhibitors of glycoprotein-41 (gp41) are able to prevent HIV infection by binding to a hydrophobic pocket (HP) contained within the gp41 ectodomain, and preventing progression of fusion. There is little structural information on gp41 – ligand complexes, owing to hydrophobicity of the...

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Bibliografiset tiedot
Julkaisussa:Org Biomol Chem
Päätekijät: Chu, Shidong, Zhou, Guangyan, Gochin, Miriam
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530879/
https://ncbi.nlm.nih.gov/pubmed/28590477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob00954b
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