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Design and characterization of swapped-domain constructs of HIV-1 glycoprotein-41 as receptors for drug discovery

Four new swapped-domain constructs of the ectodomain of human immunodeficiency virus type 1 glycoprotein-41 (gp41) were prepared. The gp41 ectodomain consists of 50-residue N-heptad repeat (NHR), 36-residue disulfide-bonded loop and 39-residue C-heptad repeat (CHR). It folds into a hairpin structure...

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Detalhes bibliográficos
Publicado no:Protein Eng Des Sel
Main Authors: Walsh, Joseph D., Chu, Shidong, Zhang, Shao-Qing, Gochin, Miriam
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366113/
https://ncbi.nlm.nih.gov/pubmed/25792539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv006
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