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Identification of Fragments Targeting an Alternative Pocket on HIV-1 gp41 by NMR Screening and Similarity Searching

[Image: see text] The HIV-1 envelope glycoprotein gp41 fusion intermediate is a promising drug target for inhibiting viral entry. However, drug development has been impeded by challenges inherent in mediating the underlying protein-protein interaction. Here we report on the identification of fragmen...

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Detalhes bibliográficos
Main Authors: Chu, Shidong, Gochin, Miriam
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817815/
https://ncbi.nlm.nih.gov/pubmed/23932360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.07.026
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