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Paramagnetic relaxation assisted docking of a small indole compound in the HIV-1 gp41 hydrophobic pocket

The hydrophobic pocket contained within the gp41 coiled coil is an important target for small molecules designed to inhibit HIV-1 fusion. While various screening experiments have identified molecules purported to bind in this pocket, few have confirmed details of the interaction, instead relying on...

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Hlavní autoři: Gochin, Miriam, Zhou, Guangyan, Phillips, Aaron
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060958/
https://ncbi.nlm.nih.gov/pubmed/21155611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb100368d
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