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Design, Synthesis and Evaluation of Indole Compounds as Novel Inhibitors targeting Gp41
A series of indole ring containing compounds were designed based on the structure of the gp41 complex in the region of the hydrophobic pocket. These compounds were synthesized using a Suzuki Coupling reaction, and evaluated using a fluorescence binding assay and cell-cell fusion assay. The observed...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2833348/ https://ncbi.nlm.nih.gov/pubmed/20153190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.111 |
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