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NMR second site screening for structure determination of ligands bound in the hydrophobic pocket of HIV-1 gp41
[Image: see text] The development of non-peptide fusion inhibitors through rational drug design has been hampered by the limited accessibility of the gp41 coiled coil target, which is highly hydrophobic, and the absence of structural data defining details of small molecule interactions. Here we desc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880620/ https://ncbi.nlm.nih.gov/pubmed/19206471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8094558 |
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