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Stable Extended Human Immunodeficiency Virus Type 1 gp41 Coiled Coil as an Effective Target in an Assay for High-Affinity Fusion Inhibitors

The human immunodeficiency virus type 1 (HIV-1) gp41 coiled-coil domain is an important target for fusion inhibitors, including the peptide T20, which has been approved as a drug against HIV-1. Research into nonpeptide fusion inhibitors has focused primarily on a hydrophobic pocket located within th...

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Bibliografske podrobnosti
Main Authors: Cai, Lifeng, Balogh, Edina, Gochin, Miriam
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687196/
https://ncbi.nlm.nih.gov/pubmed/19364877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00150-09
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