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A Novel Fluorescence Intensity Screening Assay Identifies New Low-Molecular-Weight Inhibitors of the gp41 Coiled-Coil Domain of Human Immunodeficiency Virus Type 1

A metallopeptide-based fluorescence assay has been designed for the detection of small-molecule inhibitors of human immunodeficiency virus type 1 gp41, the viral protein involved in membrane fusion. The assay involves two peptides representing the inner N-terminal-heptad-repeat (HR1) coiled coil and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cai, Lifeng, Gochin, Miriam
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913228/
https://ncbi.nlm.nih.gov/pubmed/17452484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00150-07
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