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A Fluorescence Assay for Rapid Detection of Ligand Binding Affinity to HIV-1 gp41

The fusion-active conformation of the envelope protein gp41 of HIV-1 consists of an N-terminal trimeric α-helical coiled coil domain, and three anti-parallel C-terminal helices which fold down the grooves of the coiled coil to form a six-helix bundle. Disruption of the six-helix bundle is considered...

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Hlavní autoři: Gochin, Miriam, Savage, Ryan, Hinckley, Spencer, Cai, Lifeng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2030571/
https://ncbi.nlm.nih.gov/pubmed/16606347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/BC.2006.063
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