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Antimalarials inhibit hematin crystallization by unique drug–surface site interactions
In malaria pathophysiology, divergent hypotheses on the inhibition of hematin crystallization posit that drugs act either by the sequestration of soluble hematin or their interaction with crystal surfaces. We use physiologically relevant, time-resolved in situ surface observations and show that quin...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5530657/ https://ncbi.nlm.nih.gov/pubmed/28559329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700125114 |
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