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Antimalarial 9-Anilinoacridine Compounds Directed at Hematin
Antimalarial 9-anilinoacridines are potent inhibitors of parasite DNA topoisomerase II both in vitro and in situ. 3,6-Diamino substitution on the acridine ring greatly improves parasiticidal activity against Plasmodium falciparum by targeting DNA topoisomerase II. A series of 9-anilinoacridines were...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC296215/ https://ncbi.nlm.nih.gov/pubmed/14638470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.12.3708-3712.2003 |
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