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A second mechanism employed by artemisinins to suppress Plasmodium falciparum hinges on inhibition of hematin crystallization

Malaria is a pervasive disease that affects millions of lives each year in equatorial regions of the world. During the erythrocytic phase of the parasite life cycle, Plasmodium falciparum invades red blood cells, where it catabolizes hemoglobin and sequesters the released toxic heme as innocuous hem...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ma, Wenchuan, Balta, Victoria A., West, Rachel, Newlin, Katy N., Miljanić, Ognjen Š., Sullivan, David J., Vekilov, Peter G., Rimer, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949059/
https://ncbi.nlm.nih.gov/pubmed/33239360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016115
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