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Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine
Hematin crystallization is the primary mechanism of heme detoxification in malaria parasites and the target of the quinoline class of antimalarials. Despite numerous studies of malaria pathophysiology, fundamental questions regarding hematin growth and inhibition remain. Among them are the identity...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413305/ https://ncbi.nlm.nih.gov/pubmed/25831526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501023112 |
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