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Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine
Hematin crystallization is the primary mechanism of heme detoxification in malaria parasites and the target of the quinoline class of antimalarials. Despite numerous studies of malaria pathophysiology, fundamental questions regarding hematin growth and inhibition remain. Among them are the identity...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413305/ https://ncbi.nlm.nih.gov/pubmed/25831526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501023112 |
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