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Antimalarials inhibit hematin crystallization by unique drug–surface site interactions
In malaria pathophysiology, divergent hypotheses on the inhibition of hematin crystallization posit that drugs act either by the sequestration of soluble hematin or their interaction with crystal surfaces. We use physiologically relevant, time-resolved in situ surface observations and show that quin...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5530657/ https://ncbi.nlm.nih.gov/pubmed/28559329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700125114 |
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