Targeting of Hematin by the Antimalarial Pyronaridine

Pyronaridine, 2-methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine, a new Mannich base schizontocide originally developed in China and structurally related to the aminoacridine drug quinacrine, is currently undergoing clinical testing. We now show...

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Autors principals: Auparakkitanon, Saranya, Chapoomram, Soebsakul, Kuaha, Kannika, Chirachariyavej, Thamrong, Wilairat, Prapon
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479140/
https://ncbi.nlm.nih.gov/pubmed/16723583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00119-06
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