Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase

There is a need for new antimalarials, ideally with novel mechanisms of action. Benzoxaboroles have been shown to be active against bacteria, fungi, and trypanosomes. Therefore, we investigated the antimalarial activity and mechanism of action of 3-aminomethyl benzoxaboroles against Plasmodium falci...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Sonoiki, Ebere, Palencia, Andres, Guo, Denghui, Ahyong, Vida, Dong, Chen, Li, Xianfeng, Hernandez, Vincent S., Zhang, Yong-Kang, Choi, Wai, Gut, Jiri, Legac, Jennifer, Cooper, Roland, Alley, M. R. K., Freund, Yvonne R., DeRisi, Joseph, Cusack, Stephen, Rosenthal, Philip J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
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Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958189/
https://ncbi.nlm.nih.gov/pubmed/27270277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00820-16
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