Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

The apicomplexan parasites Cryptosporidium and Toxoplasma are serious threats to human health. Cryptosporidiosis is a severe diarrheal disease in malnourished children and immunocompromised individuals, with the only FDA-approved drug treatment currently being nitazoxanide. The existing therapies fo...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Palencia, Andrés, Liu, Ru-Juan, Lukarska, Maria, Gut, Jiri, Bougdour, Alexandre, Touquet, Bastien, Wang, En-Duo, Li, Xianfeng, Alley, M. R. K., Freund, Yvonne R., Rosenthal, Philip J., Hakimi, Mohamed-Ali, Cusack, Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038320/
https://ncbi.nlm.nih.gov/pubmed/27431220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00873-16
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