Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond

Human cytosolic leucyl-tRNA synthetase (hcLRS) is an essential and multifunctional enzyme. Its canonical function is to catalyze the covalent ligation of leucine to tRNA(Leu), and it may also hydrolyze mischarged tRNAs through an editing mechanism. Together with eight other aminoacyl-tRNA synthetase...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Liu, Ru-Juan, Long, Tao, Li, Hao, Zhao, JingHua, Li, Jing, Wang, MingZhu, Palencia, Andrés, Lin, JinZhong, Cusack, Stephen, Wang, En-Duo
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229842/
https://ncbi.nlm.nih.gov/pubmed/32232361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa189
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