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Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond

Human cytosolic leucyl-tRNA synthetase (hcLRS) is an essential and multifunctional enzyme. Its canonical function is to catalyze the covalent ligation of leucine to tRNA(Leu), and it may also hydrolyze mischarged tRNAs through an editing mechanism. Together with eight other aminoacyl-tRNA synthetase...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Liu, Ru-Juan, Long, Tao, Li, Hao, Zhao, JingHua, Li, Jing, Wang, MingZhu, Palencia, Andrés, Lin, JinZhong, Cusack, Stephen, Wang, En-Duo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229842/
https://ncbi.nlm.nih.gov/pubmed/32232361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa189
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