Thiostrepton and Derivatives Exhibit Antimalarial and Gametocytocidal Activity by Dually Targeting Parasite Proteasome and Apicoplast

Ribosome-targeting antibiotics exert their antimalarial activity on the apicoplast of the malaria parasite, an organelle of prokaryote origin having essential metabolic functions. These antibiotics typically cause a delayed-death phenotype, which manifests in parasite killing during the second repli...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Aminake, Makoah N., Schoof, Sebastian, Sologub, Ludmilla, Leubner, Monika, Kirschner, Marc, Arndt, Hans-Dieter, Pradel, Gabriele
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067198/
https://ncbi.nlm.nih.gov/pubmed/21245445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01096-10
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker