Thiostrepton and Derivatives Exhibit Antimalarial and Gametocytocidal Activity by Dually Targeting Parasite Proteasome and Apicoplast

Ribosome-targeting antibiotics exert their antimalarial activity on the apicoplast of the malaria parasite, an organelle of prokaryote origin having essential metabolic functions. These antibiotics typically cause a delayed-death phenotype, which manifests in parasite killing during the second repli...

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Bibliografiset tiedot
Päätekijät: Aminake, Makoah N., Schoof, Sebastian, Sologub, Ludmilla, Leubner, Monika, Kirschner, Marc, Arndt, Hans-Dieter, Pradel, Gabriele
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2011
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Mechanisms of Action: Physiological Effects
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067198/
https://ncbi.nlm.nih.gov/pubmed/21245445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01096-10
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