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Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

Incubation of DNA with S-adenosyl-L-methionine (SAM) in neutral aqueous solution leads to base modification, with formation of small amounts of 7-methylguanine and 3-methyladenine. The products have been identified by high performance liquid chromatography of DNA hydrolysates and by the selective re...

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Bibliografiske detaljer
Main Authors: Rydberg, B, Lindahl, T
Format: Artigo
Sprog:Inglês
Udgivet: 1982
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC553022/
https://ncbi.nlm.nih.gov/pubmed/7188181
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