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Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.
Incubation of DNA with S-adenosyl-L-methionine (SAM) in neutral aqueous solution leads to base modification, with formation of small amounts of 7-methylguanine and 3-methyladenine. The products have been identified by high performance liquid chromatography of DNA hydrolysates and by the selective re...
Tallennettuna:
| Julkaisussa: | EMBO J |
|---|---|
| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
1982
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC553022/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7188181/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1982.tb01149.x |
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