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Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

Incubation of DNA with S-adenosyl-L-methionine (SAM) in neutral aqueous solution leads to base modification, with formation of small amounts of 7-methylguanine and 3-methyladenine. The products have been identified by high performance liquid chromatography of DNA hydrolysates and by the selective re...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Rydberg, B, Lindahl, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1982
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC553022/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7188181/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1982.tb01149.x
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