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The cryo-EM structure of gastric H(+),K(+)-ATPase with bound BYK99, a high-affinity member of K(+)-competitive, imidazo[1,2-a]pyridine inhibitors

The gastric proton pump H(+),K(+)-ATPase acidifies the gastric lumen, and thus its inhibitors, including the imidazo[1,2-a]pyridine class of K(+)-competitive acid blockers (P-CABs), have potential application as acid-suppressing drugs. We determined the electron crystallographic structure of H(+),K(...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Abe, Kazuhiro, Shimokawa, Jun, Naito, Mao, Munson, Keith, Vagin, Olga, Sachs, George, Suzuki, Hiroshi, Tani, Kazutoshi, Fujiyoshi, Yoshinori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529566/
https://ncbi.nlm.nih.gov/pubmed/28747707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06698-8
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