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Cryo-EM structure of gastric H(+),K(+)-ATPase with a single occupied cation-binding site

Gastric H(+),K(+)-ATPase is responsible for gastric acid secretion. ATP-driven H(+) uptake into the stomach is efficiently accomplished by the exchange of an equal amount of K(+), resulting in a luminal pH close to 1. Because of the limited free energy available for ATP hydrolysis, the stoichiometry...

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Bibliografiske detaljer
Main Authors: Abe, Kazuhiro, Tani, Kazutoshi, Friedrich, Thomas, Fujiyoshi, Yoshinori
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494912/
https://ncbi.nlm.nih.gov/pubmed/23091039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212294109
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