Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

High-throughput screening of a National Cancer Institute library of pure natural products identified the hydroxylated tropolone derivatives β-thujaplicinol (2,7-dihydroxy-4-1(methylethyl)-2,4,6-cycloheptatrien-1-one) and manicol (1,2,3,4-tetrahydro-5-7-dihydroxy-9-methyl-2-(1-methylethenyl)-6H-benzo...

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Hauptverfasser: Budihas, Scott R., Gorshkova, Inna, Gaidamakov, Sergei, Wamiru, Antony, Bona, Marion K., Parniak, Michael A., Crouch, Robert J., McMahon, James B., Beutler, John A., Le Grice, Stuart F. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC552956/
https://ncbi.nlm.nih.gov/pubmed/15741178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki268
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