Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

High-throughput screening of a National Cancer Institute library of pure natural products identified the hydroxylated tropolone derivatives β-thujaplicinol (2,7-dihydroxy-4-1(methylethyl)-2,4,6-cycloheptatrien-1-one) and manicol (1,2,3,4-tetrahydro-5-7-dihydroxy-9-methyl-2-(1-methylethenyl)-6H-benzo...

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Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Budihas, Scott R., Gorshkova, Inna, Gaidamakov, Sergei, Wamiru, Antony, Bona, Marion K., Parniak, Michael A., Crouch, Robert J., McMahon, James B., Beutler, John A., Le Grice, Stuart F. J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2005
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Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC552956/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15741178/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gki268
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