Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity()

HIV Reverse Transcriptase-associated ribonuclease H activity is a promising enzymatic target for drug development that has not been successfully targeted in the clinic. While the α-hydroxytropolone-containing natural products β-thujaplicinol and manicol have emerged as some of the most potent leads...

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Publicado en:Medchemcomm
Autores principales: Murelli, Ryan P., D'Erasmo, Michael P., Hirsch, Danielle R., Meck, Christine, Masaoka, Takashi, Wilson, Jennifer A., Zhang, Baofeng, Pal, Rajat K., Gallicchio, Emilio, Beutler, John A., Le Grice, Stuart F. J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234084/
https://ncbi.nlm.nih.gov/pubmed/28093576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6MD00238B
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