Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity()

HIV Reverse Transcriptase-associated ribonuclease H activity is a promising enzymatic target for drug development that has not been successfully targeted in the clinic. While the α-hydroxytropolone-containing natural products β-thujaplicinol and manicol have emerged as some of the most potent leads...

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Bibliografske podrobnosti
izdano v:Medchemcomm
Main Authors: Murelli, Ryan P., D'Erasmo, Michael P., Hirsch, Danielle R., Meck, Christine, Masaoka, Takashi, Wilson, Jennifer A., Zhang, Baofeng, Pal, Rajat K., Gallicchio, Emilio, Beutler, John A., Le Grice, Stuart F. J.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234084/
https://ncbi.nlm.nih.gov/pubmed/28093576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6MD00238B
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