Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase

Por Corona, Angela, Masaoka, Takashi, Tocco, Graziella, Tramontano, Enzo, Le Grice, Stuart FJ
Publicado no Future Med Chem (2013)

A cell-free enzymatic activity assay for the evaluation of HIV-1 drug resistance to protease inhibitors

Por Matsunaga, Satoko, Masaoka, Takashi, Sawasaki, Tatsuya, Morishita, Ryo, Iwatani, Yasumasa, Tatsumi, Masashi, Endo, Yaeta, Yamamoto, Naoki, Sugiura, Wataru, Ryo, Akihide
Publicado no Front Microbiol (2015)

Traceless Solid-Phase α-Hydroxytropolone Synthesis

Por D’Erasmo, Michael P., Masaoka, Takashi, Wilson, Jennifer A., Hunte, Errol M., Beutler, John A., Le Grice, Stuart F. J., Murelli, Ryan P.
Publicado no Medchemcomm (2016)

Exploiting Drug-Resistant Enzymes as Tools to Identify Thienopyrimidinone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Por Masaoka, Takashi, Chung, Suhman, Caboni, Pierluigi, Rausch, Jason W., Wilson, Jennifer A., Taskent-Sezgin, Humeyra, Beutler, John A., Tocco, Graziella, Le Grice, Stuart F. J.
Publicado em 2013

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

Por Corona, Angela, Meleddu, Rita, Esposito, Francesca, Distinto, Simona, Bianco, Giulia, Masaoka, Takashi, Maccioni, Elias, Menéndez-Arias, Luis, Alcaro, Stefano, Le Grice, Stuart F. J., Tramontano, Enzo
Publicado no PLoS One (2016)

Sesquiterpenoid Tropolone Glycosides from Liriosma ovata

Por Ma, Jun, Pawar, Rahul S., Grundel, Erich, Mazzola, Eugene P., Ridge, Clark D., Masaoka, Takashi, Le Grice, Stuart F. J., Wilson, Jennifer, Beutler, John A., Krynitsky, Alexander J.
Publicado no J Nat Prod (2015)

Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance

Por Nakashima, Masaaki, Ode, Hirotaka, Suzuki, Koji, Fujino, Masayuki, Maejima, Masami, Kimura, Yuki, Masaoka, Takashi, Hattori, Junko, Matsuda, Masakazu, Hachiya, Atsuko, Yokomaku, Yoshiyuki, Suzuki, Atsuo, Watanabe, Nobuhisa, Sugiura, Wataru, Iwatani, Yasumasa
Publicado no Front Microbiol (2016)

Studies on Cycloheptathiophene-3-Carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H inhibitors

Por Corona, Angela, Desantis, Jenny, Massari, Serena, Distinto, Simona, Masaoka, Takashi, Sabatini, Stefano, Esposito, Francesca, Manfroni, Giuseppe, Maccioni, Elias, Cecchetti, Violetta, Pannecouque, Christophe, Le Grice, Stuart F.J., Tramontano, Enzo, Tabarrini, Oriana
Publicado no ChemMedChem (2016)

Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity()

Por Murelli, Ryan P., D'Erasmo, Michael P., Hirsch, Danielle R., Meck, Christine, Masaoka, Takashi, Wilson, Jennifer A., Zhang, Baofeng, Pal, Rajat K., Gallicchio, Emilio, Beutler, John A., Le Grice, Stuart F. J.
Publicado no Medchemcomm (2016)

Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors

Por Masaoka, Takashi, Zhao, Haiyan, Hirsch, Danielle R., D'Erasmo, Michael P., Meck, Christine, Varnado, Brittany, Gupta, Ankit, Meyers, Marvin J., Baines, Joel, Beutler, John A., Murelli, Ryan P., Tang, Liang, Le Grice, Stuart F. J.
Publicado no Biochemistry (2016)

Lack of Association between Intact/Deletion Polymorphisms of the APOBEC3B Gene and HIV-1 Risk

Por Imahashi, Mayumi, Izumi, Taisuke, Watanabe, Dai, Imamura, Junji, Matsuoka, Kazuhiro, Ode, Hirotaka, Masaoka, Takashi, Sato, Kei, Kaneko, Noriyo, Ichikawa, Seiichi, Koyanagi, Yoshio, Takaori-Kondo, Akifumi, Utsumi, Makoto, Yokomaku, Yoshiyuki, Shirasaka, Takuma, Sugiura, Wataru, Iwatani, Yasumasa, Naoe, Tomoki
Publicado em 2014

Sensitivity of the C-Terminal Nuclease Domain of Kaposi's Sarcoma-Associated Herpesvirus ORF29 to Two Classes of Active-Site Ligands

Por Miller, Jennifer T., Zhao, Haiyan, Masaoka, Takashi, Varnado, Brittany, Cornejo Castro, Elena M., Marshall, Vickie A., Kouhestani, Kaivon, Lynn, Anna Y., Aron, Keith E., Xia, Anqi, Beutler, John A., Hirsch, Danielle R., Tang, Liang, Whitby, Denise, Murelli, Ryan P., Le Grice, Stuart F. J.
Publicado no Antimicrob Agents Chemother (2018)