Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

The DNA polymerase and ribonuclease H (RNase H) activities of human immunodeficiency virus type 1 (HIV-1) are needed for the replication of the viral genome and are validated drug targets. However, there are no approved drugs inhibiting RNase H and the efficiency of DNA polymerase inhibitors can be...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Corona, Angela, Meleddu, Rita, Esposito, Francesca, Distinto, Simona, Bianco, Giulia, Masaoka, Takashi, Maccioni, Elias, Menéndez-Arias, Luis, Alcaro, Stefano, Le Grice, Stuart F. J., Tramontano, Enzo
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723341/
https://ncbi.nlm.nih.gov/pubmed/26800261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147225
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