Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity

High-throughput screening of National Cancer Institute libraries of synthetic and natural compounds identified the vinylogous ureas 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide (NSC727447) and N-[3-(aminocarbonyl)-4,5-dimethyl-2-thienyl]-2-furancarboxamide (NSC727448) as inhibi...

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Detalhes bibliográficos
Main Authors: Wendeler, Michaela, Lee, Hsiu-Fang, Bermingham, Alun, Miller, Jennifer T., Chertov, Oleg, Bona, Marion K., Baichoo, Noel S., Ehteshami, Maryam, Beutler, John, O'Keefe, Barry R., Götte, Matthias, Kvaratskhelia, Mamuka, Grice, Stuart Le
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941776/
https://ncbi.nlm.nih.gov/pubmed/18831589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb8001039
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