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Mutagenesis of Human Immunodeficiency Virus Reverse Transcriptase p51 Subunit Defines Residues Contributing to Vinylogous Urea Inhibition of Ribonuclease H Activity

The vinylogous urea, NSC727447, was proposed to allosterically inhibit ribonuclease H (RNase H) activity of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) by interacting with the thumb subdomain of its non-catalytic p51 subunit. Proximity of the p51 thumb to the p66 RNase H dom...

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Библиографические подробности
Главные авторы: Chung, Suhman, Miller, Jennifer T., Johnson, Barry C., Hughes, Stephen H., Le Grice, Stuart F. J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281700/
https://ncbi.nlm.nih.gov/pubmed/22105069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.314781
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